Abstract
In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon cancer cell line SW480 that their constituent parts do not.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / pharmacology
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Bridged-Ring Compounds
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Cell Line, Tumor / drug effects
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Colonic Neoplasms
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Drug Design
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Drug Screening Assays, Antitumor
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Guanosine / analogs & derivatives*
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Humans
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Microtubules / drug effects
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Paclitaxel / analogs & derivatives*
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Structure-Activity Relationship
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Taxoids
Substances
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Antineoplastic Agents, Phytogenic
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Bridged-Ring Compounds
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Taxoids
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Guanosine
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taxane
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Paclitaxel