Hypocholesterolemic activity of hesperetin derivatives

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2663-5. doi: 10.1016/s0960-894x(03)00574-2.

Abstract

Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticholesteremic Agents / chemical synthesis*
  • Anticholesteremic Agents / pharmacology
  • Body Weight
  • Cholesterol / blood
  • Cholesterol, Dietary / administration & dosage
  • Ethers / chemical synthesis
  • Ethers / pharmacology
  • Hesperidin / chemical synthesis
  • Hesperidin / chemistry*
  • Hesperidin / pharmacology
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy
  • Mice
  • Structure-Activity Relationship
  • Time Factors

Substances

  • Anticholesteremic Agents
  • Cholesterol, Dietary
  • Ethers
  • hesperetin 7-O-lauryl ether
  • hesperetin 7-O-oleyl ether
  • Cholesterol
  • Hesperidin
  • hesperetin