A contradictory treatment for lysosomal storage disorders: inhibitors enhance mutant enzyme activity

Trends Pharmacol Sci. 2003 Jul;24(7):355-60. doi: 10.1016/S0165-6147(03)00158-5.
No abstract available

Publication types

  • Review

MeSH terms

  • Enzyme Inhibitors / pharmacology*
  • Glucosylceramidase / antagonists & inhibitors
  • Glucosylceramidase / genetics*
  • Humans
  • Lysosomal Storage Diseases* / drug therapy
  • Lysosomal Storage Diseases* / enzymology
  • Molecular Chaperones / pharmacology
  • Mutation
  • Protein Folding
  • alpha-Galactosidase / antagonists & inhibitors
  • alpha-Galactosidase / genetics*

Substances

  • Enzyme Inhibitors
  • Molecular Chaperones
  • alpha-Galactosidase
  • Glucosylceramidase