Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb

Cell Death Differ. 2003 Aug;10(8):930-2. doi: 10.1038/sj.cdd.4401251.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / analogs & derivatives*
  • Acetylcysteine / pharmacology
  • Amino Acid Chloromethyl Ketones / pharmacology
  • Antioxidants / pharmacology
  • Apoptosis / drug effects*
  • Blotting, Western
  • Caspase 3
  • Caspase 8
  • Caspases / drug effects
  • Caspases / metabolism
  • Cell Line, Tumor / drug effects
  • Cell Survival / drug effects
  • Cysteine Endopeptidases
  • Cytochromes c / drug effects
  • Cytochromes c / metabolism
  • Dose-Response Relationship, Drug
  • Flow Cytometry
  • Humans
  • Leupeptins / pharmacology*
  • Membrane Potentials / drug effects
  • Microscopy, Fluorescence
  • Mitochondria / drug effects
  • Mitochondria / physiology
  • Multienzyme Complexes / antagonists & inhibitors
  • Osteosarcoma / metabolism
  • Osteosarcoma / pathology
  • Protease Inhibitors / pharmacology
  • Proteasome Endopeptidase Complex
  • Proto-Oncogene Proteins c-bcl-2 / drug effects
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Reactive Oxygen Species / metabolism
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / physiology*
  • Time Factors
  • Transfection
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / physiology
  • bcl-X Protein

Substances

  • Amino Acid Chloromethyl Ketones
  • Antioxidants
  • BCL2L1 protein, human
  • Leupeptins
  • Multienzyme Complexes
  • Protease Inhibitors
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53
  • bcl-X Protein
  • benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
  • retinoblastoma protein p95
  • lactacystin
  • Cytochromes c
  • CASP3 protein, human
  • CASP8 protein, human
  • Caspase 3
  • Caspase 8
  • Caspases
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex
  • benzyloxycarbonylleucyl-leucyl-leucine aldehyde
  • Acetylcysteine