Influence of new gamma-hydroxybutyric acid amide analogues on the central nervous system activity in mice

Pol J Pharmacol. 2002 Nov-Dec;54(6):731-6.

Abstract

The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the gamma-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Central Nervous System / drug effects*
  • Central Nervous System / physiology
  • Hydroxybutyrates / chemical synthesis*
  • Hydroxybutyrates / pharmacology*
  • Hydroxybutyrates / therapeutic use
  • Male
  • Mice
  • Seizures / chemically induced
  • Seizures / prevention & control
  • Sleep / drug effects
  • Sleep / physiology
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Hydroxybutyrates
  • 4-hydroxybutyric acid
  • gamma-Aminobutyric Acid