Abstract
In contrast to 5'-O-carbonate 3TC derivatives (23, 24), which are clearly 3TC prodrugs, the corresponding 3TC carbamates (15-21 and 25), found to be very stable compounds with respect to enzymatic hydrolysis (cellular lysates and culture cell media) and still active on both HIV-1 and HBV infected cells, may not be 3TC prodrugs. The antiviral properties as well as the mechanism of action of 3TC analogues have been studied and evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / metabolism
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Anti-HIV Agents / pharmacology*
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Antiviral Agents / metabolism
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Antiviral Agents / pharmacology*
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Cell Line
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Culture Media
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Deoxycytidine / analogs & derivatives
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Deoxycytidine / metabolism
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Deoxycytidine / pharmacology*
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HIV-1 / drug effects
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Hepatitis B virus / drug effects*
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Humans
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Prodrugs / metabolism
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Prodrugs / pharmacology*
Substances
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5'-O-carbamate-2',3'-dideoxythiacytidine
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Anti-HIV Agents
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Antiviral Agents
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Culture Media
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Prodrugs
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Deoxycytidine