Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line

J Med Chem. 2003 Jul 17;46(15):3185-8. doi: 10.1021/jm020548b.

Abstract

Several bioactive acetogenins were selective against 1A9 (ovarian cancer) cell replication but did not show a corresponding hyperactivity against other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for other cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Propanol / chemistry*
  • Annonaceae / chemistry
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Drug Screening Assays, Antitumor
  • Fatty Acids / chemistry
  • Fatty Acids / isolation & purification
  • Fatty Acids / pharmacology*
  • Female
  • Furans / chemistry
  • Furans / isolation & purification
  • Furans / pharmacology*
  • Humans
  • Ovarian Neoplasms
  • Plant Preparations / chemistry
  • Plant Preparations / isolation & purification
  • Plant Preparations / pharmacology
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Fatty Acids
  • Furans
  • Plant Preparations
  • 2-Propanol