Assessment of pubertal development in juvenile male rats after sub-acute exposure to bisphenol A and nonylphenol

Toxicol Lett. 2003 Aug 28;143(3):261-70. doi: 10.1016/s0378-4274(03)00172-3.

Abstract

The effects of bisphenol A and nonylphenol on pubertal development in the intact juvenile/peripubertal male Sprague-Dawley rats was observed in this study from PND23-52/53. Two groups of rats were administered orally with either 100 mg/kg body weight of nonylphenol or bisphenol A. Another group of rats were administered orally with a mixture of 100 mg/kg body weight of nonylphenol and bisphenol A. Control group was administered with the vehicle of Tween-80 with corn oil (1:9 v/v). Observations made in this study included growth, age at preputial separation, thyroid, liver, testis and kidney weight and histology, epididymal and seminal vesicle plus coagulation gland weight. Nonylphenol and bisphenol A have been observed to cause delay in puberty onset as well as testicular damage in the treatment groups when compared to the control; spermatogenesis was affected in most treated rats. Bisphenol A also caused the enlargement of the kidney and hydronephrosis. Administration of nonylphenol and bisphenol A as a mixture has caused less than additive effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzhydryl Compounds
  • Body Weight / drug effects
  • Estrogens, Non-Steroidal / toxicity*
  • Histocytochemistry
  • Kidney / drug effects
  • Kidney / pathology
  • Liver / drug effects
  • Liver / pathology
  • Male
  • Organ Size / drug effects
  • Phenols / toxicity*
  • Rats
  • Rats, Sprague-Dawley
  • Sexual Maturation / drug effects*
  • Testis / drug effects
  • Testis / pathology
  • Thyroid Gland / drug effects
  • Thyroid Gland / pathology

Substances

  • Benzhydryl Compounds
  • Estrogens, Non-Steroidal
  • Phenols
  • nonylphenol
  • bisphenol A