Abstract
Cases of fluconazole-resistant Cryptococcus neoformans have been reported in AIDS patients previously treated with fluconazole. We report a case of fluconazole-resistant cryptococcal meningitis in an HIV-negative patient not previously exposed to fluconazole. The patient experienced a clinical relapse after discontinuation of therapy with amphotericin B and subsequent initiation of fluconazole therapy. In vitro resistance was initially verified by Etest and tablet diffusion and later confirmed by NCCLS broth microdilution.
MeSH terms
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Aged
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Cryptococcus neoformans / classification
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Cryptococcus neoformans / drug effects*
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Cryptococcus neoformans / isolation & purification
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Drug Resistance, Fungal
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Fluconazole / pharmacology
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Fluconazole / therapeutic use*
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HIV Seronegativity*
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
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Male
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Meningitis, Cryptococcal / diagnosis
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Meningitis, Cryptococcal / drug therapy*
Substances
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Antifungal Agents
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Fluconazole