Outbreak of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 enzyme in Curitiba, Brazil

J Clin Microbiol. 2003 Jul;41(7):3403-6. doi: 10.1128/JCM.41.7.3403-3406.2003.

Abstract

Carbapenem-resistant Acinetobacter baumannii isolates were obtained from eight patients in two hospitals in Curitiba, Brazil. The isolates were multiresistant, belonged to a single strain, and produced the OXA-23 carbapenemase. Treatment options were limited, although the isolates were susceptible to polymyxin B in vitro. The strain contributed to the deaths of five patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / enzymology
  • Adult
  • Aged
  • Aged, 80 and over
  • Brazil / epidemiology
  • Carbapenems / pharmacology*
  • Disease Outbreaks*
  • Drug Resistance, Bacterial*
  • Hospitals, Teaching
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • beta-Lactamases / metabolism*

Substances

  • Carbapenems
  • beta-lactamase OXA-23
  • beta-Lactamases