Eudesmane derivatives from Laggera pterodonta

Fitoterapia. 2003 Jul;74(5):459-63. doi: 10.1016/s0367-326x(03)00106-0.

Abstract

A new eudesmane derivative, 4alpha,5alpha-dihydroxyeudesma-11(13)-en-12-oic acid, was isolated from Laggera pterodonta. Its structure was elucidated as (1) on the basis of spectroscopic evidence. Moreover, six known compounds were isolated: pterodontriol A (2), pterodontriol B, pterodonta acid (3), ilicic acid (4), costic acid and beta-amyrin. Cytotoxic activity of compounds 2, 3 and 4 was investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Asteraceae*
  • Cell Division / drug effects
  • Humans
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes / therapeutic use
  • Sesquiterpenes, Eudesmane*
  • Tumor Cells, Cultured / drug effects

Substances

  • 4alpha,5alpha-dihydroxyeudesma-11(13)-en-12-oic acid
  • Antineoplastic Agents
  • Plant Extracts
  • Sesquiterpenes
  • Sesquiterpenes, Eudesmane
  • eudesmane