Abstract
A new eudesmane derivative, 4alpha,5alpha-dihydroxyeudesma-11(13)-en-12-oic acid, was isolated from Laggera pterodonta. Its structure was elucidated as (1) on the basis of spectroscopic evidence. Moreover, six known compounds were isolated: pterodontriol A (2), pterodontriol B, pterodonta acid (3), ilicic acid (4), costic acid and beta-amyrin. Cytotoxic activity of compounds 2, 3 and 4 was investigated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Asteraceae*
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Cell Division / drug effects
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Humans
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Phytotherapy*
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology*
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Sesquiterpenes / therapeutic use
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Sesquiterpenes, Eudesmane*
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Tumor Cells, Cultured / drug effects
Substances
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4alpha,5alpha-dihydroxyeudesma-11(13)-en-12-oic acid
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Antineoplastic Agents
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Plant Extracts
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Sesquiterpenes
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Sesquiterpenes, Eudesmane
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eudesmane