Synthesis of carbocyclic nucleosides as potential antiviral agents

A Kozaki; F Zulfiqar; Y Ueno; Y Kitade

doi:10.1093/nass/1.1.59

Synthesis of carbocyclic nucleosides as potential antiviral agents

Nucleic Acids Res Suppl. 2001:(1):59-60. doi: 10.1093/nass/1.1.59.

Authors

A Kozaki¹, F Zulfiqar, Y Ueno, Y Kitade

Affiliation

¹ Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.

PMID: 12836263
DOI: 10.1093/nass/1.1.59

Abstract

Treatment of 1-[(1'R,2'S,3'S,4'S)-4'-methanesulfonyl-2',3'-O- isopropylidenedioxycyclopentan-1'-yl]-1-H-uracil with LiN3 gave 1-[(1'R,2'S,3'R)-2',3'-O-isopropylidenedioxy-4'- cyclopenten-1'-yl]-1-H-uracil. When KOBut was added instead of LiN3, 1-[(1'R,2'S)-2',3'-O- isopropylidenedioxy-3'-cyclopenten-1'-yl]-1-H-uracil was produced. An analogous treatment of the methanesulfonyl derivative of thymine was also carried out.

MeSH terms

Acids, Carbocyclic / chemistry
Antiviral Agents / chemical synthesis*
Antiviral Agents / chemistry
Pyrimidine Nucleosides / chemical synthesis*
Pyrimidine Nucleosides / chemistry

Substances

Acids, Carbocyclic
Antiviral Agents
Pyrimidine Nucleosides