Poly(oligonucleotide) conjugates: applications in assembling nanoparticles and in detecting DNA sequences

R L Letsinger; C A Mirkin; S J Park; G Viswanadham; L Zhang

doi:10.1093/nass/1.1.1

Poly(oligonucleotide) conjugates: applications in assembling nanoparticles and in detecting DNA sequences

Nucleic Acids Res Suppl. 2001:(1):1-2. doi: 10.1093/nass/1.1.1.

Authors

R L Letsinger¹, C A Mirkin, S J Park, G Viswanadham, L Zhang

Affiliation

¹ Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

PMID: 12836234
DOI: 10.1093/nass/1.1.1

Abstract

The chemistry of oligonucleotide-nanoparticle conjugates is described. Examples are provided to illustrate (i) the utility of oligonucleotide linkers in constructing ordered nanoparticle assemblies and (ii) applications of nanoparticles as reporters for nucleic acid hybridization.

Publication types

Evaluation Study
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Gold / chemistry
Nucleic Acid Hybridization / methods*
Oligonucleotide Probes / chemistry*
Oligonucleotides / chemistry
Polymers / chemistry
Sequence Analysis, DNA

Substances

Oligonucleotide Probes
Oligonucleotides
Polymers
Gold

Grants and funding

GM57356/GM/NIGMS NIH HHS/United States