Cluster ions and residue nanoparticles with sizes below 30 nm were generated by electrospraying (ES) and drying droplets of pure water, tap water, and aqueous solutions of salts. The mobility spectra of the cluster ions between 9.1 and 9.3 x 10(-5) m2/(V s) were measured using a differential mobility analyzer (DMA) operated at room temperature and atmospheric pressure. A modified Faraday cup and a condensation nucleus counter were used for detection. The concentrations of total residue/contaminants in the water were determined as a function of sizes of measured aerosol particles and of the initial droplets. Method detection limits were at sub-ppb level for pure water and sub-ppm level for tap water. ES/DMA is capable of simultaneously measuring the mobility distribution of cluster ions and concentration of total residue present in water samples.