Abstract
Clinical examination and conduction velocity measurements in peripheral nerves have been done on 56 patients with non-Hodgkin's lymphomas of high malignancy (NHL). It is suggested that: the evaluation of the influence of chemotherapy on peripheral nervous system (PNS) is possible by means of systematic neurological and electroneurographic studies; electroneurographic assessment is most important in the diagnosis of early subclinical stages of peripheral neuropathy; toxic influence of CBVPM/AVBP protocol on PNS is greater than CHOP schedule; impairment of PNS due to chemotherapy is reversible in patients during complete remission (CR).
MeSH terms
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Adolescent
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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Bleomycin / adverse effects
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects
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Female
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Humans
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Lymphoma, Non-Hodgkin / drug therapy*
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Lymphoma, Non-Hodgkin / physiopathology
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Male
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Median Nerve / drug effects*
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Median Nerve / physiopathology
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Methotrexate / administration & dosage
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Methotrexate / adverse effects
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Middle Aged
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Neural Conduction / drug effects
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Neural Conduction / physiology
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Peroneal Nerve / drug effects*
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Peroneal Nerve / physiopathology
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Prednisone / administration & dosage
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Prednisone / adverse effects
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Reflex, Abnormal / drug effects*
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Reflex, Abnormal / physiology
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Reflex, Stretch / drug effects*
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Reflex, Stretch / physiology
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Ulnar Nerve / drug effects*
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Ulnar Nerve / physiopathology
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Vincristine / administration & dosage
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Vincristine / adverse effects
Substances
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Bleomycin
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone
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Methotrexate
Supplementary concepts
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AVBP protocol
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CBVPM protocol
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CHOP protocol