Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark

J Nat Prod. 2003 Jun;66(6):891-3. doi: 10.1021/np020599b.

Abstract

The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Blood Platelets
  • Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
  • Ear
  • Edema
  • Enzyme Inhibitors / pharmacology
  • Erythrina / chemistry*
  • Female
  • Humans
  • Isoflavones / chemistry
  • Isoflavones / isolation & purification*
  • Isoflavones / pharmacology
  • Leukocytes / drug effects
  • Leukotriene B4 / antagonists & inhibitors
  • Mice
  • Molecular Structure
  • Phospholipases A / pharmacology
  • Plant Bark / chemistry
  • Plants, Medicinal / chemistry*
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Rats
  • Rats, Wistar

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Enzyme Inhibitors
  • Isoflavones
  • Leukotriene B4
  • warangalone
  • Prostaglandin-Endoperoxide Synthases
  • Cyclic AMP-Dependent Protein Kinases
  • Phospholipases A