Abstract
The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Blood Platelets
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Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
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Ear
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Edema
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Enzyme Inhibitors / pharmacology
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Erythrina / chemistry*
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Female
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Humans
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Isoflavones / chemistry
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Isoflavones / isolation & purification*
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Isoflavones / pharmacology
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Leukocytes / drug effects
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Leukotriene B4 / antagonists & inhibitors
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Mice
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Molecular Structure
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Phospholipases A / pharmacology
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Rats
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Rats, Wistar
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Enzyme Inhibitors
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Isoflavones
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Leukotriene B4
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warangalone
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Prostaglandin-Endoperoxide Synthases
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Cyclic AMP-Dependent Protein Kinases
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Phospholipases A