Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child

Pediatr Infect Dis J. 2003 Jun;22(6):570-2.

Abstract

We describe a case of poliomyelitis in a 3-year-old Argentinean boy with X-linked hypogammaglobulinemia. The child had no history of polio vaccination, but a poliovirus isolated from a stool sample had 97.2% genetic similarity to the Sabin 1 vaccine strain. According to the WHO definition, this is the first case reported of a vaccine-derived poliovirus infection recorded in continental Latin America.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / immunology*
  • Child, Preschool
  • Feces / virology
  • Follow-Up Studies
  • Humans
  • Immunocompromised Host*
  • Latin America
  • Male
  • Paralysis / diagnosis
  • Paralysis / etiology
  • Poliomyelitis / diagnosis
  • Poliomyelitis / etiology*
  • Poliovirus / isolation & purification*
  • Poliovirus Vaccine, Oral / administration & dosage
  • Poliovirus Vaccine, Oral / adverse effects*
  • Risk Assessment
  • Vaccination / adverse effects

Substances

  • Poliovirus Vaccine, Oral