Gene therapy in the treatment of intestinal inflammation

Catherine van Montfrans; Anje A te Velde; Sander J H van Deventer; Maria Sol Rodriguez Pena

doi:10.1007/s00384-003-0501-4

Gene therapy in the treatment of intestinal inflammation

Int J Colorectal Dis. 2004 Mar;19(2):79-86. doi: 10.1007/s00384-003-0501-4. Epub 2003 Jun 25.

Authors

Catherine van Montfrans¹, Anje A te Velde, Sander J H van Deventer, Maria Sol Rodriguez Pena

Affiliation

¹ Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

PMID: 12827411
DOI: 10.1007/s00384-003-0501-4

Abstract

Background: Local expression of anti-inflammatory or immunoregulatory genes may offer an alternative treatment of gastrointestinal inflammation.

Discussion: We review the basic requirements for gene therapy, the possible routes of delivery, and the different strategies for specific targeting focusing on gastrointestinal inflammation.

Publication types

Review

MeSH terms

Gastroenteritis / therapy*
Gene Targeting
Gene Transfer Techniques
Genetic Therapy / methods*
Genetic Vectors
Humans
Transcription, Genetic