Purpose: To describe the frequency and clinical characteristics of chorioretinal lesions as a complication of chronic granulomatous disease (CGD).
Methods: Seventeen patients with CGD examined at Seoul National University Children's Hospital between 1996 and 1999 were recruited for this study. A review of their historical, clinical, and fluorescein angiographic features was performed, and the prevalence and demographic and clinical features of the chorioretinal lesions were summarized.
Results: Chorioretinal lesions were identified in 11 eyes of six patients with CGD, an overall prevalence of 35.3%. Patients' ages ranged from 6 months to 10 years, with a median of 47.0 months. Three of the six patients were boys. The lesions included RPE atrophy or pigment clumping, chorioretinal atrophy. Among the six patients, two had vision loss because of ischemia in the peripheral retina, neovascular membrane, and macular edema, which had not been previously reported.
Conclusions: Chorioretinal lesions are not uncommon in patients with CGD and they may affect vision. Regular screening of patients with CGD and long-term follow-up of CGD chorioretinopathy patients should be performed to define the lesion, natural history, and pathogenesis.