Abstract
Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more potent activity against Gram-negative bacteria than globomycin and also exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Indicators and Reagents
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Microbial Sensitivity Tests
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Peptides / chemical synthesis*
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Peptides / pharmacology*
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology*
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Indicators and Reagents
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Peptides
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Protease Inhibitors
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globomycin