Antimycobacterial activity of 1-substituted indolizines

Lise-Lotte Gundersen; Ayele H Negussie; Frode Rise; Ole Benny ØStby

doi:10.1002/ardp.200390019

Antimycobacterial activity of 1-substituted indolizines

Arch Pharm (Weinheim). 2003 Jun;336(3):191-5. doi: 10.1002/ardp.200390019.

Authors

Lise-Lotte Gundersen¹, Ayele H Negussie, Frode Rise, Ole Benny ØStby

Affiliation

¹ Department of Chemistry, University of Oslo, Blindern, Norway. l.l.gundersen@kjemi.uio.no

PMID: 12822185
DOI: 10.1002/ardp.200390019

Abstract

Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H(37)Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an alpha-hydroxybenzyl substituent in the indolizine 1-position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 microg/mL

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Indolizines / chemical synthesis*
Indolizines / chemistry
Indolizines / pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Structure-Activity Relationship

Substances

Antitubercular Agents
Indolizines