Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate

Antimicrob Agents Chemother. 2003 Jul;47(7):2330-3. doi: 10.1128/AAC.47.7.2330-2333.2003.

Abstract

An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carbapenems / pharmacology
  • Drug Resistance, Bacterial
  • Environment
  • Genes, Bacterial
  • Molecular Sequence Data
  • RNA, Ribosomal, 16S / genetics
  • Serratia / drug effects
  • Serratia / enzymology*
  • Serratia / genetics*
  • beta-Lactamases / genetics*

Substances

  • Carbapenems
  • RNA, Ribosomal, 16S
  • beta-Lactamases

Associated data

  • GENBANK/AB003148
  • GENBANK/AF197943
  • GENBANK/AJ250876
  • GENBANK/AJ251239
  • GENBANK/AJ308331
  • GENBANK/AY236502
  • GENBANK/M11189
  • GENBANK/M63556
  • GENBANK/S71932
  • GENBANK/X57102
  • GENBANK/X75074
  • GENBANK/X96858
  • GENBANK/Y10415
  • GENBANK/Y18050