Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa

M Carmen Conejo; Isabel García; Luis Martínez-Martínez; Leandro Picabea; Alvaro Pascual

doi:10.1128/AAC.47.7.2313-2315.2003

Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa

Antimicrob Agents Chemother. 2003 Jul;47(7):2313-5. doi: 10.1128/AAC.47.7.2313-2315.2003.

Authors

M Carmen Conejo¹, Isabel García, Luis Martínez-Martínez, Leandro Picabea, Alvaro Pascual

Affiliation

¹ Department of Microbiology, School of Medicine, University of Seville, Seville, Spain. cconejo@us.es

Abstract

The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbapenems / pharmacology*
Drug Resistance, Bacterial
Latex
Microbial Sensitivity Tests
Porins / biosynthesis*
Pseudomonas aeruginosa / drug effects*
Pseudomonas aeruginosa / growth & development
Pseudomonas aeruginosa / metabolism
Silicon
Urinary Catheterization / adverse effects*
Zinc / pharmacology*

Substances

Carbapenems
Latex
Porins
OprD protein, Pseudomonas aeruginosa
Zinc
Silicon