Pharmacokinetic and tumour-photosensitizing properties of methoxyphenyl porphyrin derivative

Biomed Pharmacother. 2003 May-Jun;57(3-4):163-8. doi: 10.1016/s0753-3322(03)00030-1.

Abstract

The photokilling activity of 5-[4-N-(2',6'-dinitro-4'-trifluoromethylphenyl) aminophenyl]-10,15,20-tris(2,4,6-trimethoxy phenyl) porphyrin (CF3) was evaluated on a Hep-2 human larynx-carcinoma cell line. An apoptotic mechanism of cell death was found at low irradiation doses. Pharmacokinetic and tumour-photosensitizing properties were studied in mice. The results show that a different mechanism of cell death can be induced depending on the irradiation doses in the photodynamic treatments with CF3, which makes this agent an interesting sensitizer for potential tumour photosensitizer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Count
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Female
  • Humans
  • Liposomes
  • Mice
  • Mice, Inbred BALB C
  • Phloroglucinol / analogs & derivatives*
  • Phloroglucinol / pharmacokinetics*
  • Phloroglucinol / pharmacology*
  • Photic Stimulation
  • Photochemotherapy
  • Photosensitizing Agents / pharmacokinetics*
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / pharmacokinetics*
  • Porphyrins / pharmacology*
  • Tissue Distribution

Substances

  • 5-(4-N-(N-2',6'-dinitro-4'-trifluoromethylphenyl)aminophenyl)-10,15,20-tris(2,4,6-trimethoxyphenyl)porphyrin
  • Liposomes
  • Photosensitizing Agents
  • Porphyrins
  • Phloroglucinol