Ultrasound effect on the aromatic nucleophilic substitution reactions on some haloarenes

Ultrason Sonochem. 2003 Jul;10(4-5):265-70. doi: 10.1016/S1350-4177(02)00157-8.

Abstract

The sonochemical nucleophilic aromatic substitutions on haloarenes with different amines have been studied. A beneficial ultrasound effect was observed and high yields of the products were obtained after 15-30 min sonication. The reaction course of the nucleophilic aromatic substitution was found to be strongly dependent on nucleophilicity, bulkiness, and boiling point of amines as well as on the electron-withdrawing property of the substituents on the haloarenes.