Comparison between the effects of the rapid recombinant insulin analog Lispro (Lys B28, Pro B29) and those of human regular insulin on platelet cyclic nucleotides and aggregation

Thromb Res. 2003 Mar 15;109(5-6):323-7. doi: 10.1016/s0049-3848(03)00255-x.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Adult
  • Androstadienes / pharmacology
  • Blood Platelets / chemistry
  • Blood Platelets / drug effects*
  • Cyclic AMP / blood*
  • Cyclic GMP / blood*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Insulin / analogs & derivatives*
  • Insulin / pharmacology*
  • Insulin Lispro
  • Male
  • Nitric Oxide / physiology
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Phosphoinositide-3 Kinase Inhibitors
  • Platelet Aggregation / drug effects*
  • Recombinant Proteins / pharmacology
  • Wortmannin
  • omega-N-Methylarginine / pharmacology

Substances

  • Androstadienes
  • Enzyme Inhibitors
  • Insulin
  • Insulin Lispro
  • Phosphoinositide-3 Kinase Inhibitors
  • Recombinant Proteins
  • omega-N-Methylarginine
  • Nitric Oxide
  • Adenosine Diphosphate
  • Cyclic AMP
  • Nitric Oxide Synthase
  • Cyclic GMP
  • Wortmannin