Methylergometrine is often used in the management of the third stage of labor and for treatment of prevention of puerperal hemorrhage. Intoxication in newborns is rare but may lead to severe complications. We reviewed 34 cases of methylergometrine poisoning that occurred in Belgium between 1969 and 1999. Fourteen patients were newborns and 20 were older children. Twenty-nine patients were exposed by the oral route, 3 by the intranasal route, and 2 by the intramuscular route. Oral exposure was associated mostly with gastrointestinal symptoms, but one newborn required mechanical ventilation for apnea. Intramuscular exposure was associated with severe complications, including apnea, coma, and convulsions. We describe the first case of oral methylergometrine poisoning requiring mechanical ventilation and alert physicians that oral exposure to methylergometrine may lead to severe complications.