The heart weight and heart weight/body weight (HW/BW) ratio were assessed in an adult autopsy population and compared with commonly used reference values. Examination of 127 adult post-mortem cases (80 males and 47 females, aged 17 to 91 years) revealed that the mean heart weight and the HW/BW ratios of both genders were significantly greater than the reference values, particularly so in the hypertensive patients. These findings suggest that the Jamaican adult heart is significantly heavier than values used from reference tables. In both genders, heart weight was significantly and positively correlated with body weight and body mass index but not height, for non-hypertensive and hypertensive subjects. The present data are preliminary and not comprehensive enough to establish definitive reference values for the Jamaican population. However, this information needs to be taken into consideration when making pathologic diagnoses using heart weight as a criterion in post-mortem diagnosis.