Diterpenoid and phenolic glycosides from the roots of Rhododendron molle

Planta Med. 2003 May;69(5):434-9. doi: 10.1055/s-2003-39716.

Abstract

Two new grayanane diterpenoid glucosides, rhodomosides A (1), B (2) and two new phenolic glycosides 3, 4 together with a known glucosyringic acid (5) were isolated from the roots of Rhododendron molle G. Don (Ericaceae). Their structures were elucidated on the basis of spectral analysis. Compounds 3, 4 and 5 were found to inhibit the proliferation of murine B lymphocytes in vitro, while compound 3 also showed stimulatory activity on the proliferation of murine T lymphocytes in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / drug effects*
  • Cyclosporine / pharmacology
  • Diterpenes / pharmacology*
  • Glycosides / pharmacology*
  • Immunosuppressive Agents / pharmacology*
  • Mice
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Roots
  • Rhododendron*
  • Spleen / cytology
  • T-Lymphocytes / drug effects*

Substances

  • Diterpenes
  • Glycosides
  • Immunosuppressive Agents
  • Plant Extracts
  • Cyclosporine