Abstract
Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the molecular basis for increased thrombogenicity of cell membranes.
MeSH terms
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Animals
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Aorta, Thoracic / injuries
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Aorta, Thoracic / metabolism
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Aorta, Thoracic / radiation effects
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Cell Membrane / metabolism*
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Cell Membrane / radiation effects*
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Dose-Response Relationship, Radiation
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Gamma Rays
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In Vitro Techniques
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Iodine Radioisotopes
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Kinetics
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Membrane Lipids / metabolism
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Membrane Lipids / radiation effects
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Phospholipids / metabolism
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Phospholipids / radiation effects
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Prothrombin / metabolism*
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Radiation Injuries / metabolism
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Sus scrofa
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Thrombosis / etiology
Substances
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Iodine Radioisotopes
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Membrane Lipids
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Phospholipids
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Prothrombin