Effect of radiation on prothrombin interactions with cell membrane fragments

Bull Exp Biol Med. 2002 Nov;134(5):442-4. doi: 10.1023/a:1022630011907.

Abstract

Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the molecular basis for increased thrombogenicity of cell membranes.

MeSH terms

  • Animals
  • Aorta, Thoracic / injuries
  • Aorta, Thoracic / metabolism
  • Aorta, Thoracic / radiation effects
  • Cell Membrane / metabolism*
  • Cell Membrane / radiation effects*
  • Dose-Response Relationship, Radiation
  • Gamma Rays
  • In Vitro Techniques
  • Iodine Radioisotopes
  • Kinetics
  • Membrane Lipids / metabolism
  • Membrane Lipids / radiation effects
  • Phospholipids / metabolism
  • Phospholipids / radiation effects
  • Prothrombin / metabolism*
  • Radiation Injuries / metabolism
  • Sus scrofa
  • Thrombosis / etiology

Substances

  • Iodine Radioisotopes
  • Membrane Lipids
  • Phospholipids
  • Prothrombin