Effect of fluoridated dentifrice and acidulated phosphate fluoride application on early artificial carious lesions

Am J Dent. 2003 Apr;16(2):91-5.

Abstract

Purpose: To evaluate the effect of a combination of fluoride dentifrice and acidulated phosphate fluoride (APF) on enamel with incipient caries lesions.

Materials and methods: Bovine dental enamel blocks with artificial caries lesions were divided into four treatment groups and submitted to a pH-cycling model: (1) Placebo non-fluoridated dentifrice (PD); (2) Fluoridated dentifrice (FD), 1,100 ppm F; (3) APF (12,300 ppm F, pH 3.5) + PD; 4) APF+FD. APF was applied to enamel blocks of groups APF+PD and APF+FD before the pH-cycling regimen and all of them were exposed to dentifrice during the cycling.

Results: The results showed that 61-81% of the fluoride previously deposited in enamel by APF was released to the media during the pH-cycling. The final concentration of fluoride in enamel in the group APF+PD was lower than that before the cycling (P < 0.05), but in the group APF+FD the reduction was not significant (P> 0.05). FD treatment was significantly more efficient than PD in rehardening the enamel surface and increasing the hardness of the caries lesions. APF+PD treatment was not more efficient than PD in increasing enamel hardness and an additive effect of APF+FD was not observed.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidulated Phosphate Fluoride / therapeutic use
  • Analysis of Variance
  • Animals
  • Cariostatic Agents / administration & dosage
  • Cariostatic Agents / pharmacokinetics
  • Cariostatic Agents / therapeutic use*
  • Cattle
  • Dental Caries / drug therapy*
  • Dental Enamel / metabolism
  • Dental Enamel Solubility
  • Dentifrices / chemistry
  • Fluorides / administration & dosage
  • Fluorides / pharmacokinetics
  • Fluorides / therapeutic use*
  • Hardness
  • Saliva / chemistry
  • Statistics, Nonparametric
  • Tooth Remineralization

Substances

  • Cariostatic Agents
  • Dentifrices
  • Acidulated Phosphate Fluoride
  • Fluorides