The pathogenesis of intraneural ganglion cysts is unknown. Some authors have established a connection between the cysts and the joint, while others have failed to find this communication. Most intraneural ganglion cysts occur in the proximity of a joint. We present the case of a 53-year-old Caucasian male with an intraneural cyst of the sciatic nerve located high above its bifurcation and without a connection to the joint. The lesion was microsurgically removed in toto. There was no recurrence of the cyst at follow-up 9 months postoperatively; complete resolution of the clinical symptoms occurred within 8 months of surgery. This case shows that ganglion cysts can occur in locations far from a joint, supporting the extra-articular embryonic synovial remnant theory of their genesis.