Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides

Ping Gu; Jordi Morral; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Erik De Clercq; Piet Herdewijn

doi:10.1177/095632020301400103

Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides

Antivir Chem Chemother. 2003 Jan;14(1):31-7. doi: 10.1177/095632020301400103.

Authors

Ping Gu¹, Jordi Morral, Jing Wang, Jef Rozenski, Roger Busson, Arthur Van Aerschot, Erik De Clercq, Piet Herdewijn

Affiliation

¹ Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.

PMID: 12790514
DOI: 10.1177/095632020301400103

Abstract

A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6-diaminopurine analogue.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
Antiviral Agents / toxicity
Cell Division / drug effects
Cell Line
Cyclohexanes / chemistry
Herpesvirus 1, Human / drug effects
Herpesvirus 2, Human / drug effects
Humans
Microbial Sensitivity Tests
Models, Chemical
Nucleosides / chemical synthesis*
Nucleosides / pharmacology*
Structure-Activity Relationship

Substances

Antiviral Agents
Cyclohexanes
Nucleosides