Chemical anesthesia of northern sea otters (Enhydra lutris): results of past field studies

J Zoo Wildl Med. 2001 Jun;32(2):181-9. doi: 10.1638/1042-7260(2001)032[0181:CAONSO]2.0.CO;2.

Abstract

Between 1987 and 1997, we chemically immobilized 597 wild sea otters (Enhydra lutris) in Alaska for the collection of biological samples or for surgical instrumentation. One drug-related sea otter fatality occurred during this time. Fentanyl in combination with diazepam produced consistent, smooth inductions with minimal need for supplemental anesthetics during procedures lasting 30-40 min. Antagonism with naltrexone or naloxone was rapid and complete, although we observed narcotic recycling in sea otters treated with naloxone. For surgical procedures, we recommend a fentanyl target dose of 0.33 mg/kg of body mass and diazepam at 0.11 mg/kg. For nonsurgical biological sample collection procedures, we recommend fentanyl at 0.22 mg/kg and diazepam at 0.07 mg/kg. We advise the use of the opioid antagonist naltrexone at a ratio of 2:1 to the total fentanyl administered during processing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anesthesia / adverse effects
  • Anesthesia / methods
  • Anesthesia / veterinary*
  • Anesthetics, Combined* / administration & dosage
  • Anesthetics, Combined* / adverse effects
  • Anesthetics, Combined* / antagonists & inhibitors
  • Anesthetics, Intravenous / administration & dosage
  • Anesthetics, Intravenous / adverse effects
  • Anesthetics, Intravenous / antagonists & inhibitors
  • Animals
  • Azaperone / administration & dosage
  • Azaperone / adverse effects
  • Azaperone / antagonists & inhibitors
  • Body Temperature / drug effects
  • Diazepam / administration & dosage
  • Diazepam / adverse effects
  • Diazepam / antagonists & inhibitors
  • Female
  • Fentanyl / administration & dosage
  • Fentanyl / adverse effects
  • Fentanyl / antagonists & inhibitors
  • Heart Rate / drug effects
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / adverse effects
  • Hypnotics and Sedatives / antagonists & inhibitors
  • Immobilization*
  • Logistic Models
  • Male
  • Naloxone / pharmacology
  • Naltrexone / pharmacology
  • Narcotic Antagonists / pharmacology
  • Otters / physiology*
  • Respiration / drug effects
  • Seizures / chemically induced
  • Seizures / veterinary
  • Time Factors
  • Tremor / chemically induced
  • Tremor / veterinary

Substances

  • Anesthetics, Combined
  • Anesthetics, Intravenous
  • Hypnotics and Sedatives
  • Narcotic Antagonists
  • Azaperone
  • Naloxone
  • Naltrexone
  • Diazepam
  • Fentanyl