Abstract
The urokinase-receptor (u-PAR) is a central molecule of invasion and metastasis promoting plasminogen-dependent extracellular matrix degradation in diverse carcinoma types such as gastric or colon cancer. Overexpression of u-PAR has been reported to occur mainly at the transcriptional level in malignant cells, and has been shown to indicate a poor clinical prognosis of cancer patients. This review will give an overview on experimental findings on u-PAR and its function, molecular mechanisms of its regulation, and its impact for future clinical decision planning and potential therapeutic concepts.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biomarkers, Tumor
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Extracellular Matrix / metabolism
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Gene Expression Regulation, Neoplastic*
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Humans
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Neoplasms / metabolism
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Neoplasms / therapy*
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Phenotype
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Protein Binding
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Receptors, Cell Surface / biosynthesis*
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / physiology*
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Receptors, Urokinase Plasminogen Activator
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Signal Transduction
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Transcription, Genetic
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Urokinase-Type Plasminogen Activator / metabolism
Substances
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Biomarkers, Tumor
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PLAUR protein, human
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Receptors, Cell Surface
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Receptors, Urokinase Plasminogen Activator
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Urokinase-Type Plasminogen Activator