The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in mice

Eur J Pharmacol. 2003 May 30;470(1-2):95-7. doi: 10.1016/s0014-2999(03)01779-5.

Abstract

The effect of the GABA(B) receptor agonist baclofen, a potential treatment for gastroesophageal reflux, on gastric emptying has not been determined. The effect of 1-4 mg/kg baclofen on liquid and solid gastric emptying in mice was evaluated by noninvasive [13C] breath tests. Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Baclofen / pharmacology*
  • Female
  • GABA Agonists / pharmacology*
  • GABA-B Receptor Agonists*
  • Gastric Emptying / drug effects*
  • Gastric Emptying / physiology
  • Mice
  • Mice, Inbred C57BL
  • Receptors, GABA-B / physiology

Substances

  • GABA Agonists
  • GABA-B Receptor Agonists
  • Receptors, GABA-B
  • Baclofen