Abstract
To investigate the mechanisms involved in hemin-induced febrile response, the rectal temperature of rats were measured after intracerebroventricular (i.c.v.) injections of hemin, with or without antagonists. Hemin (10 microg) elicited a significant febrile response, which lasted from 30 min, to more than 6 h, after its administration, but this was not the case with biliverdin (i.c.v.) and bilirubin (i.c.v.). The hemin-induced febrile response was significantly inhibited by pretreatment with an inhibitor of tyrosine kinase (genistein), but not by pretreatment with an inhibitor of protein kinase C (chelerythrine) and a scavenger of iron (deferoxamine). These results suggest that tyrosine kinase is involved in the hemin-induced febrile response.
MeSH terms
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Alkaloids
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Animals
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Benzophenanthridines
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Body Temperature / drug effects
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Deferoxamine / administration & dosage
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Deferoxamine / pharmacology
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Fever / chemically induced
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Fever / enzymology
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Fever / metabolism*
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Genistein / administration & dosage
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Genistein / pharmacology
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Heme Oxygenase (Decyclizing) / metabolism
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Hemin / administration & dosage
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Hemin / metabolism*
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Injections, Intraventricular
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Iron Chelating Agents / administration & dosage
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Iron Chelating Agents / pharmacology
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Male
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Phenanthridines / administration & dosage
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Phenanthridines / pharmacology
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Protein Kinase C / antagonists & inhibitors
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Protein-Tyrosine Kinases / metabolism*
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Pyrogens / administration & dosage
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Pyrogens / metabolism*
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Rats
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Rats, Sprague-Dawley
Substances
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Alkaloids
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Benzophenanthridines
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Iron Chelating Agents
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Phenanthridines
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Pyrogens
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Hemin
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Genistein
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chelerythrine
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Heme Oxygenase (Decyclizing)
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Protein-Tyrosine Kinases
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Protein Kinase C
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Deferoxamine