[Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer]

Zhonghua Wai Ke Za Zhi. 2003 Feb;41(2):93-5.
[Article in Chinese]

Abstract

Objective: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer.

Methods: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain.

Results: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer.

Conclusion: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Clusterin / metabolism*
  • Clusterin / physiology
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Prostate / metabolism*
  • Prostatic Hyperplasia / metabolism*
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / physiopathology

Substances

  • Clusterin