Eighty patients with periodontal inflammations and 15 subjects matched for age and sex without periodontal inflammations were examined. Periodontal status was evaluated using clinical and paraclinical methods of examination. Blood content and oxygen saturation of periodontal tissues were evaluated with an Escort II MDE saturator (USA). The results indicate that interval normobaric hypoxic stimulation promoted a decrease of bacterial contamination of periodontal pouches and notably improved blood content and oxygen saturation of periodontal tissues.