Design of copper DNA intercalators with leishmanicidal activity

J Biol Inorg Chem. 2003 Apr;8(4):401-8. doi: 10.1007/s00775-002-0427-2. Epub 2003 Jan 7.

Abstract

The complexes [Cu(dppz)(NO(3))]NO(3) (1), [Cu(dppz)(2)(NO(3))]NO(3) (2), [Cu(dpq)(NO(3))]NO(3) (3), and [Cu(dpq)(2)(NO(3))]NO(3) (4) were synthesized and characterized by elemental analysis, FAB-mass spectrometry, EPR, UV, and IR spectroscopies, and molar conductivity. DNA interaction studies showed that intercalation is an important way of interacting with DNA for these complexes. The biological activity of these copper complexes was evaluated on Leishmania braziliensis promastigotes, and the results showed leishmanicidal activity. Preliminary ultrastructural studies with the most active complex (2) at 1 h revealed parasite swelling and binucleated cells. This finding suggests that the leishmanicidal activity of the copper complexes could be associated with their interaction with the parasitic DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Copper / chemistry*
  • Copper / metabolism
  • DNA / chemistry*
  • DNA / metabolism
  • Drug Design*
  • Intercalating Agents / chemical synthesis*
  • Intercalating Agents / metabolism
  • Intercalating Agents / pharmacology*
  • Leishmania braziliensis / drug effects*
  • Leishmania braziliensis / growth & development*
  • Leishmania braziliensis / metabolism

Substances

  • Intercalating Agents
  • Copper
  • DNA