The aim of this study was to evaluate lipid peroxidation status and anti-oxidant defenses in chronic hemodialysis patients comparison with healthy persons (control group). Forty-six hemodialysis patients were included in the study group and 66 healthy persons in control group. We determined the plasma levels of malondialdehyde as s biomarker of oxidative stress and the concentration of ceruloplasmin and activity catalase as antioxidant defenses. Our investigation indicate that the concentration of malondialdehyde increased 1.7 times in hemodialysis patients and activity of catalase decreased in 56.2% cases. Hyperlipidemia was evaluated in 20% of patients and hypoalbuminaemia in 6.6%. Most of these patients (48.8%) were found to have a history of occlusive vascular artery disease either coronary (17.7%), cerebral (11.1%) or peripheral (15.5%) occlusive disease. In conclusion these results suggest that intensity of lipid peroxidation and decreased plasma antioxidant potential in association with hyperlipidemia and hypoalbuminaemia may contribute to the increased risk of cardiovascular disease.