IB-00208, a new cytotoxic polycyclic xanthone produced by a marine-derived Actinomadura. I. Isolation of the strain, taxonomy and biological activites

J Antibiot (Tokyo). 2003 Mar;56(3):219-25. doi: 10.7164/antibiotics.56.219.

Abstract

A new compound, IB-00208, has been isolated from the fermentation broth of an actinomycete isolated from a marine environment. The strain was identified as Actinomadura sp. by its chemical and phylogenetic characteristics. The compound shows cytotoxic activity on tumor cell lines and bactericidal activity against gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales / chemistry*
  • Actinomycetales / classification
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / classification
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / classification
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Base Sequence
  • DNA, Bacterial / chemistry
  • DNA, Ribosomal / chemistry
  • Fermentation
  • Glucosides / chemistry
  • Glucosides / classification
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Microscopy, Electron, Scanning
  • Molecular Sequence Data
  • Molecular Structure
  • Phylogeny
  • Xanthenes / chemistry
  • Xanthenes / classification
  • Xanthenes / isolation & purification*
  • Xanthenes / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • DNA, Bacterial
  • DNA, Ribosomal
  • Glucosides
  • IB 00208
  • Xanthenes