Blood testosterone (T), androstenedione (A) and dehydroisoandrosterone (DHA) were simultaneously measured, using radioimmunoassay, in six healthy (control) females and eight various subjects, before (J1), during (J2) and after (J3) metopirone administration. The variation pattern of each androgen is different during the test. The mean value of each androgen at each time, point and the percentage decrease between J2 and J3 related to J2 are considered. Each step of the test (increase and decrease) is discussed with reference to published data and variations of response obeserved in the eight non control subjects.