A novel peptide synthesis using fluorous chemistry

Mamoru Mizuno; Kohtaro Goto; Tsuyoshi Miura; Daisuke Hosaka; Toshiyuki Inazu

doi:10.1039/b300682d

A novel peptide synthesis using fluorous chemistry

Chem Commun (Camb). 2003 Apr 21:(8):972-3. doi: 10.1039/b300682d.

Authors

Mamoru Mizuno¹, Kohtaro Goto, Tsuyoshi Miura, Daisuke Hosaka, Toshiyuki Inazu

Affiliation

¹ The Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan.

PMID: 12744325
DOI: 10.1039/b300682d

Abstract

Three new fluorous supports for peptide synthesis, i.e., the trialkoxybenzhydryl-type (6), the Wang-type (7) and the tert-butyl-type support (8), were prepared. A bioactive peptide TRH was easily synthesized by an Fmoc strategy using the benzhydryl-type fluorous support with fluorous chemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Amino Acids / chemistry
Chromatography, High Pressure Liquid
Fluorenes / chemistry
Hydrocarbons, Fluorinated / chemistry*
Resins, Synthetic / chemistry
Resins, Synthetic / classification
Thyrotropin-Releasing Hormone / chemical synthesis*

Substances

Amino Acids
Fluorenes
Hydrocarbons, Fluorinated
N(alpha)-fluorenylmethyloxycarbonylamino acids
Resins, Synthetic
Thyrotropin-Releasing Hormone