Abstract
Forty-five patients with non-insulin-dependent diabetes mellitus (NIDDM) were enrolled in the study. Before and after the 2-week treatment course of oral erythromycin, esophageal (the mean transit time, MTT) and gastric motility (the halftime of gastric emptying, GETt1/2) were evaluated by radionuclide labeled liquid and solid meals. Meanwhile, the fasting blood sugar (FBS) levels were monitored. After a 2-week erythromycin treatment, MTT shortened from 9.32+/-1.12 to 6.28+/-0.91 s and GETt1/2 shortened from 210.2+/-24.3 to 128.3+/-30.1 min. Meanwhile, FBS decreased from 198.2+/-30.1 to 121.5+/-21.3 mg/dl (P value <.05). We conclude that a 2-week treatment course of oral erythromycin can significantly improve esophageal and gastric motility which results in a better control of blood sugar in patients with NIDDM.
MeSH terms
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Administration, Oral
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Adult
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Aged
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Blood Glucose / analysis
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / physiopathology
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Digestive System Physiological Phenomena*
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Erythromycin / administration & dosage
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Erythromycin / therapeutic use*
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Esophagus / drug effects
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Esophagus / physiopathology*
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Fasting
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Female
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Gastric Emptying / drug effects
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Gastrointestinal Agents / administration & dosage
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Gastrointestinal Agents / therapeutic use
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Gastrointestinal Diseases / drug therapy*
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Gastrointestinal Diseases / etiology
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Gastrointestinal Diseases / physiopathology
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Gastrointestinal Motility / drug effects*
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Gastrointestinal Transit / drug effects
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Gastrointestinal Transit / physiology
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Glycated Hemoglobin / analysis
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Humans
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Hypoglycemic Agents / therapeutic use
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Male
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Middle Aged
Substances
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Blood Glucose
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Gastrointestinal Agents
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Glycated Hemoglobin A
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Hypoglycemic Agents
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Erythromycin