Abstract
We review the role of somatic mutations and genetic instability in the pathogenesis of atherosclerosis, suggesting novel therapeutic approaches.
MeSH terms
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Animals
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Arteriosclerosis / drug therapy
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Arteriosclerosis / genetics*
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Arteriosclerosis / physiopathology
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Cell Division / genetics*
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DNA Damage / drug effects
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DNA Damage / genetics*
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Humans
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Hypertrophy / drug therapy
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Hypertrophy / genetics*
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Hypertrophy / physiopathology
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Inflammation / genetics*
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Lipoproteins, LDL / metabolism
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / metabolism*
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Mutation / drug effects
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Mutation / genetics
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Oxidative Stress / drug effects
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Oxidative Stress / genetics