Genetic instability, DNA damage and atherosclerosis

Cell Cycle. 2003 May-Jun;2(3):224-7.

Abstract

We review the role of somatic mutations and genetic instability in the pathogenesis of atherosclerosis, suggesting novel therapeutic approaches.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / drug therapy
  • Arteriosclerosis / genetics*
  • Arteriosclerosis / physiopathology
  • Cell Division / genetics*
  • DNA Damage / drug effects
  • DNA Damage / genetics*
  • Humans
  • Hypertrophy / drug therapy
  • Hypertrophy / genetics*
  • Hypertrophy / physiopathology
  • Inflammation / genetics*
  • Lipoproteins, LDL / metabolism
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / metabolism*
  • Mutation / drug effects
  • Mutation / genetics
  • Oxidative Stress / drug effects
  • Oxidative Stress / genetics

Substances

  • Lipoproteins, LDL