Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Geoffrey P Margison; Andrew C Povey; Bernd Kaina; Mauro F Santibáñez Koref

doi:10.1093/carcin/bgg005

Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Carcinogenesis. 2003 Apr;24(4):625-35. doi: 10.1093/carcin/bgg005.

Authors

Geoffrey P Margison¹, Andrew C Povey, Bernd Kaina, Mauro F Santibáñez Koref

Affiliation

¹ Cancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. gmargison@picr.man.ac.uk

PMID: 12727789
DOI: 10.1093/carcin/bgg005

Abstract

O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alkylation
Amino Acid Sequence
Chromatin / chemistry
Chromatin / metabolism
DNA / metabolism
Humans
Molecular Sequence Data
O(6)-Methylguanine-DNA Methyltransferase / chemistry
O(6)-Methylguanine-DNA Methyltransferase / metabolism*
O(6)-Methylguanine-DNA Methyltransferase / physiology
Phosphorylation
Promoter Regions, Genetic
Sequence Homology, Amino Acid
Transcription Factors / metabolism

Substances

Chromatin
Transcription Factors
DNA
O(6)-Methylguanine-DNA Methyltransferase