Abstract
Transition metal complexes are located at the active sites of a number of enzymes involved in intriguing biochemical reactions. These complexes can exhibit a wide variety of chemical reactivity due to the ease at which transition metals can adopt different coordination environments and oxidation states. Crystallography has been a powerful technique for examining the structure and conformational variability of complex biological metallocenters. In particular, the past ten years have provided a wealth of structural information and several surprises concerning the metallocenters at the active sites of nitrogenase, hydrogenase and carbon monoxide dehydrogenase/acetyl-coenzyme A synthase.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aldehyde Oxidoreductases / chemistry*
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Aldehyde Oxidoreductases / metabolism
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Binding Sites
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Coenzymes / chemistry
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Coenzymes / metabolism
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Crystallography / methods*
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Enzyme Activation
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Hydrogenase / chemistry*
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Hydrogenase / metabolism
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Iron / chemistry*
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Metals / chemistry
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Metals / metabolism
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Models, Molecular*
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Multienzyme Complexes / chemistry*
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Multienzyme Complexes / metabolism
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Nickel / chemistry*
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Nitrogenase / chemistry*
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Nitrogenase / metabolism
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Protein Binding
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Protein Conformation
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Substrate Specificity
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Transition Elements / chemistry
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Transition Elements / metabolism
Substances
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Coenzymes
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Metals
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Multienzyme Complexes
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Transition Elements
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Nickel
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Iron
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Hydrogenase
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Nitrogenase
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Aldehyde Oxidoreductases
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carbon monoxide dehydrogenase