Do current sequence analysis algorithms disclose multifunctional (moonlighting) proteins?

Bioinformatics. 2003 May 1;19(7):895-6. doi: 10.1093/bioinformatics/btg111.

Abstract

A number of multifunctional, 'moonlighting', proteins have been analyzed by different current programs to test whether they identify both functions. PSI-BLAST and PRODOM perform best in predicting the alternative function.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Algorithms*
  • Databases, Protein
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / classification*
  • Proteomics / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • Structure-Activity Relationship*

Substances

  • Proteins