Trypsin inhibitory effect of wedelolactone and demethylwedelolactone

Phytother Res. 2003 Apr;17(4):420-1. doi: 10.1002/ptr.1153.

Abstract

Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.

MeSH terms

  • Animals
  • Chickens
  • Coumarins / pharmacology*
  • Eclipta*
  • Humans
  • Inhibitory Concentration 50
  • Ovum / drug effects
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Protease Inhibitors / pharmacology*
  • Trypsin / drug effects*

Substances

  • Coumarins
  • Plant Extracts
  • Protease Inhibitors
  • wedelolactone
  • demethylwedelolactone
  • Trypsin